Publications

Reviews:

Biology of Cancer-Testis Antigens and Their Therapeutic Implications in Cancer; Dawn Sijin Non, Lih-Wen Deng; Cells, 2023 Mar 17;12(6):926.doi: 10.3390/cells12060926. PMID: 36980267

How germline genes promote malignancy in cancer cells. Jan Willem Bruggeman, Jan Koster, Ans M M van Pelt , Dave Speijer, Geert Hamer; Bioessays, 2023 Jan;45(1):e2200112. doi: 10.1002/bies.202200112, PMID: 36300921

Cancer and meiotic gene expression: Two sides of the same coin? Ieng Fong Sou, Geert Hamer, Wee-Wei Tee, Gerben Vader, Urszula Lucja McClurg; Curr Top Dev Biol. 2023:151:43-68. doi: 10.1016/bs.ctdb.2022.06.002. PMID: 36681477

Emerging Contributions of Cancer/Testis Antigens to Neoplastic Behaviors; Zane Gibbs, Angelique Whitehurst; Trends Cancer, 2018 Oct;4(10):701-712. doi: 10.1016/j.trecan.2018.08.005. PMID: 30292353

Cancer/testis (CT) antigens: potential targets for immunotherapy; Otavia Cabarello, Yao-Tseng Chen; Cancer Sci. 2009 Nov;100(11):2014-21. doi: 10.1111/j.1349-7006.2009.01303.x. PMID: 19719775

Cancer/testis antigens, gametogenesis and cancer; Andrew J G Simpson, Otavia L Caballero, Achim Jungbluth, Yao-Tseng Chen, Lloyd J Old; Nat Rev Cancer, 2005 Aug;5(8):615-25. doi: 10.1038/nrc1669. PMID: 16034368

Cancer/testis antigens: an expanding family of targets for cancer immunotherapy; Matthew J Scanlan, Ali O Gure, Achim A Jungbluth, Lloyd J Old, Yao-Tseng Chen; Immunol Rev. 2002 Oct:188:22-32. doi: 10.1034/j.1600-065x.2002.18803.x. PMID: 12445278

Cancer is a somatic cell pregnancy; Lloyd J Old; Cancer Immun .2007 Nov 6:7:19. PMID: 17983204 (editorial)

Research:

Ectopic expression of testis-specific transcription elongation factor in driving cancer; Zheng, B.…Shilatifard, A; Sci Adv, 2025 Mar 14;11(11):eads4200. doi: 10.1126/sciadv.ads4200. PMID: 40085698

MAGE-A4 induces non-small cell lung cancer and tumor-promoting plasma cell accumulation. Armstrong, D….Kheradmand F., Sci Adv 2025 Feb 14;11(7): eads4227. doi: 10.1126/sciadv.ads4227. PMID: 39937892

A survey of human cancer-germline genes: Linking X chromosome localization, DNA methylation and sex-biased expression in early embryos; Loriat, A…De Smet, C; PLoS Genet, 2025 Oct 15;21(10):e1011734. doi: 10.1371/journal.pgen.1011734, PMID: 41091706

ABL1-mediated tyrosine phosphorylation of SYCP2 contributes to transcription-coupled homologous recombination and platinum resistance in ovarian cancer, Gao, B….Lan, Li. NAR Cancer, 2025 Sep 3;7(3):zcaf031. doi: 10.1093/narcan/zcaf031. PMID: 40918650

L-2-hydroxyglutarate regulates centromere and heterochromatin conformation in the male germline. Mayorek, N…Pikarsky, E.; PLoS Genet, 2025 Jul 10;21(7):e1011785. doi: 10.1371/journal.pgen.1011785. PMID: 40638696

Germline specific genes increase DNA double-strand break repair and radioresistance in lung adenocarcinoma cells; Liu, W…Hamer, G; Cell Death Dis. 2024 Jan 12;15(1):38. doi: 10.1038/s41419-024-06433-y. PMID: 38216586

Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair; Wang, Y…Lan, L. Nat Commun, 2024 Feb 21;15(1):1568. doi: 10.1038/s41467-024-45693-2. PMID: 38383600

In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer; Dervovic, D…Schramek, D. Nat Commun. 2023 May 31;14(1):3150.doi: 10.1038/s41467-023-38841-7. PMID: 37258521

Single-Cell Evolutionary Analysis Reveals Drivers of Plasticity and Mediators of Chemoresistance in Small Cell Lung Cancer; Wollenzien, H.,…Kareta, M. Mol. Can. Res. 2023 Sep 1;21(9):892-907. doi: 10.1158/1541-7786.MCR-22-0881. PMID: 37256926